The shoot is happening in London and Cruise is seen making a big leap between two buildings.
However the 55-year-old appears to come up short on the landing and hits the side of the building.
Tom Cruise is known for performing his own stunts in movies, but the danger is completely real.
After hoisting himself onto the building, Cruise limps before collapsing near crew members.
Over 30 people killed in Nepal floods and landslides
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The actor is now in London shooting the highly-anticipated action flick. At the time of reporting, Cruise's representatives had not answered requests for comment from outlets actively reporting on the situation, including The Hollywood Reporter.
The extent of the injuries Cruise sustained this weekend isn't clear at the time of writing, but by the looks of the video, he suffered quite a bit of pain.
Tom is now on set in London and he was wearing a safety harness during the time of the accident.
"I was scared s--less", Cruise admitted of his "Mission: Impossible 5" stunt.
Chief Christopher McQuarrie is returning for the 6th portion of the establishment, which is set to hit theaters July 27, 2018. Also starring are Henry Cavill, Rebecca Ferguson, Angela Bassett and Alec Baldwin.