President Jacob Zuma is again potentially facing 783 counts of money laundering, racketeering and fraud - eight years after the charges were first laid.
Zuma and the NPA had asked for leave to appeal a judgment of the Gauteng North High Court previous year, which ruled in favour of the Democratic Alliance (DA), setting aside the 2009 decision by the NPA's then National Director of Public Prosecution, Mokotedi Mpshe, to discontinue the corruption case against Zuma.
President Zuma and the NPA have also been ordered to pay the costs of the failed application.
The charges relate to Mr Zuma's relationship with a businessman, Shabir Shaik, who was tried and found guilty in 2005 of soliciting bribes from a French arms company "for the benefit of Zuma".
The court held that Mpshe's decision was irrational. These so-called tapes were given to the National Prosecuting Authority (NPA) as part of Zuma's "representations" as to why he should not be prosecuted.
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The camera was pointing right at the couple's bed. It was supposed to be a relaxing holiday for Derek Starnes and his wife. Robert Bourque told WFLA , who said police are searching for more victims who might have been unknowingly recorded.
It is the corruption case that will not go away.
The case against him was dropped in controversial circumstances in 2009, when the security services produced recordings of phone conversations that apparently show there was "political meddling" by prosecutors.
"But what we should be looking at, there is no way that this country can trust the NPA, which is compromised by the virtue of of the fact that they joined Zuma to appeal, which means that they are not willing to prosecute". The charges now stand‚ and a court of law must hear this matter.
The rand extended gains against the dollar after the Supreme Court's ruling, which was unanimous.
In practice, many believe South Africa's National Prosecuting Authority is unlikely to proceed, at least not without further delays.