It was only in March 2017 that another Goodison Park-based Republic of Ireland global, right-back Seamus Coleman, also suffered a leg break during a 2018 FIFA World Cup qualifier against Wales.
On Saturday, James McCarthy was the next Irishman to suffer a serious leg break and it came in the most unfortunate of circumstances.
The Venezuela global was involved in a second-half collision which resulted in the Everton midfielder suffering a double leg fracture.
Chris Brunt's whipped cross nearly caught Pickford out 10 minutes later as West Brom continued to soak up Everton pressure and hit the hosts on the counter attack.
McCarthy picked up the injury as he made a challenge on Rondon, who immediately signalled to the sidelines that the 27-year-old required treatment.
Coleman, who was watching the match from a directors' box high up in the stands, is reported to have come down to the pitch to comfort McCarthy as he was stretchered off down the tunnel.
Rondon himself was even in tears in the aftermath of the incident.
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James McCarthy on the ground in pain after the incident.
The Venezuelan striker accidentally struck McCarthy's standing leg, horrifically injuring the Toffees ace.
"Salomon was traumatised", Pardew said.
- Everton (@Everton) January 20, 2018An unfortunate clash with Saloman Rondon looks to have seriously injured James McCarthy.
Rondon chased after the ref to blow the whistle for the medical team to get on the pitch.