According to police report, the 20-year-old singer and two military officers were on board a Jeep with registration AS 497-16 from Sunyani heading towards Kumasi when it collided head-on with a VIP bus heading towards Sunyani from Kumasi.
Ebony's passing comes on the back of a stellar 2017 where she rose to superstardom in Ghanaian popular culture.
Ebony Reigns recently shared a heart-warming picture with Dr Lawrence Tetteh on social media.
The two others in the vehicle with her were also killed in the crash, while the driver of the bus is receiving treatment in hospital.
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Black Stars captain Asamoah Gyan paid a vibrant tribute to the late Dancehall artiste, Priscilla Opoku Kwarteng, who is known in the entertainment industry as "Ebony Reigns".
A video spotted by ghafla.com sees Ebony in the same attire happily conversing with some group of people believed to be her family members. She was signed to Bullet's Rufftown record label a day after. She had been tipped by many Ghanaians to win the 2017 artiste of the year when the Ghana Music Awards is held in March this year.
Ebony Reigns came out with her first single, "Dancefloor", in December 2015 with a video and audio release.
Some of her songs include; "Sponsor", "Maame Hw3", "Hustle" etc.