Mignolet has shared goalkeeper duties with Loris Karius this season, with the former having been first choice in the Premier League and the latter chosen to start in the Champions League. Two games have ended in favour of Liverpool and two have ended in draws.
Emre Can joins the travelling party despite being suspended for the first leg, and the Merseyside club will travel to Spain after the match for some warm-weather training.
"I'm going over to Portugal myself next week and hopefully we can get a good result and see where it takes us". We go there with belief. It's good, really good.
Porto conceded ten goals during the group stage, second-worst among the teams that qualified for the last-16.
"We will fight for everything tomorrow".
Manchester United will be hoping that their own Ivorian superstar - Eric Bailly - can return to action in time for their Round of 16 meeting with Sevilla next week, although according to ESPN, the centre-back faces a race against time to pass fit.
Ghana's Waris Majeed, signed in the January window on loan from FC Lorient, has been included in Porto's Champions League squad, and could be a fascinating trump card for coach Sergio Conceicao. On Wednesday, the Porto boss could be without as many as five first-team players due to various fitness concerns as well as suspension.
Porto, a two-time European champion, has never beaten Liverpool in four previous attempts.
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Porto are yet to repeat their Jose Mourinho-inspired triumph of 2004 and lift the European Cup for a third time in their history, but they continue to punch at or above their weight against the continent's great names. Mo's come in and got 22 (league) goals.
"Does that happen a lot in the Champions League?".
The 26-year-old forward has been in top form this season, scoring 20 goals in 28 matches with Porto.
While Coutinho's fellow countryman Firmino has scored 19 times in 31 games so far this term. In addition to that, I think Liverpool will score many goals and that means that the over 2.5 goals is a bet which I also like.
Writing in his column for Sky Sports, Nicholas said: "I'm not surprised Liverpool are favourites here". "I don't know yet if he'll be available on Wednesday, but I think he has a chance", explained the the gaffer, keeping his cards close to his chest.
The Reds are the second top scorers in the Premier League this season but have struggled at the back, and Gerrard says the club must play to their strengths when they step out at the Estádio do Dragão.
"It's normal to talk about Mo and Roberto, and it's also normal for people to sometimes overlook a player's contribution - but I don't oversee it".
Somewhat bizarrely Klopp was then asked whether Liverpool could win the tie in the first leg.