The interstate was closed down in both directions after the crash.
According to district officials, the students were out of state for a school trip to Disney World in Florida, when the bus carrying the band instruments and a small portion of students crashed. The station reported that 52 people are on board the bus. Multiple people were taken to Sacred Heart Hospital in Pensacola.
"We have multiple injuries; the bus went down into a ravine", said Chris Elliott, a Baldwin County commissioner who helped out at the county emergency management center following the crash.
Safety records for the bus company show they have been involved in four crashes in the last two years including another fatal accident.
Rescue crews work at the scene of a deadly charter bus crash on Tuesday, March 13, 2018, in Loxley, Ala. A school district spokesman told the Houston Chronicle that high school band students were traveling on the bus.
The tour bus crashed on Interstate 10 about 5:30 a.m., Malone said at the press conference.
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Rescuers used every piece of equipment on every truck to reach them, Mack said: "This is what we call an all-out". He said at least one person had to be cut out of the wreckage.
Several units are on the scene, including helicopters that are taking patients to medical centers in Baldwin County, Mobile, Alabama, and Pensacola, Florida.
"A couple people from the community called and asked if they could bring shirts or blankets to the hospitals", Davidson said.
"At this time, we have been able to confirm that 40 students and 6 adults from Channelview were on the bus at the time of the accident".
Lowery said uninjured passengers will be reunited with family members and Channelview school officials at Coastal Church on County Road 64 in Daphne, Alabama.
First Class Tours, the bus company carrying the students, said in a statement, "Our prayers are with the injured and their families at this time".
A serious accident has taken place involving a First Class Tours bus in Alabama this morning.