Jose Mourinho must hope his cautious tactics in Spain are not what costs his side across the two legs.
His double inside the first 25 minutes means Rashford has more goals from one game than Alexis Sanchez has managed for United since signing the most lucrative contract in Premier League history in January.
Manchester United boss Jose Mourinho is ready to splash out £180million on three new signings this summer, with two of them reportedly from Tottenham.
"Frank de Boer - seven matches, seven defeats [sic], zero goals - where he was saying that it was not good for Marcus Rashford to have a coach like me because the most important thing for me is to win".
Elsewhere Ander Herrera will likely miss out due to a muscle injury, while Zlatan Ibrahimovic is still out for the long-term with a knee injury. They now sit fifth in the table, 11 points behind fourth place Valencia. With that in mind, a good run in this season's competition is what the Spanish side will be looking for.
Boosted by breaking his drought, Rashford then swept home a second 10 minutes later with the Liverpool defence again scrambling after Lukaku had outmuscled Dejan Lovren.
Zidane on Sergio Ramos' quick exit: He s
A sloppy pass out from the back by Anaitz Arbilla conceded possession to Modric, who quickly picked out Ronaldo. Real Madrid is another four points back in third.
However, with City seemingly just a few weeks away from sealing the title and having already booked their place in the Champions League quarter-finals, the pressure is on United to join them in Friday's draw when they host Sevilla on Tuesday.
And he wasn't part of the training session open to the media on Monday morning as United prepared for their Champions League round-of-16 second leg. He's very young, he needs games. United had clearly identified the channel between Alexander-Arnold and Lovren as one to attack and they did exactly that through Rashford.
Sevilla will be without the services of Sebastien Corchia and Jesus Navas, who are both still injured.
Lionel Carole likewise has a calf injury, but Juan Soriano could feature after overcoming a shoulder problem.
In the marquee clash of the weekend in England, Liverpool travelled to Manchester United in the latest round of their fierce rivalry.
Sevilla have lost two of their last four games, conceding seven goals.
This season, there is no Europa League safety net, but Manchester United doesn't have the same worries about Champions League qualification.
Lenglet has said that Sevilla will "put everything" on the table as they bid to upset the Red Devils at Old Trafford.