UCL?Sevilla forward Wissam Ben Yedder lit up Old Trafford with two goals to send his side through to the Champions League quarter finals on Tuesday night.
Then, lest we forget, there is the financial gulf between these clubs, along with Sevilla's struggles at times this season and the fact they had never won on English soil before.
Manchester United's Serbian midfielder Nemanja Matic (L) and Manchester United's Ivorian defender Eric Bailly react after Sevilla scored their first goal during a last 16 second leg UEFA Champions League football match between Manchester United and Sevilla at Old Trafford in Manchester. Mourinho's team breezed through theirs, although elimination at the hands of Sevilla is bordering on a disaster.
"It's not the end of the world", he said. You can concede with more time to play.
"We had good situations and good periods, we didn't have control because the opponent had control, but I can not say my players had something wrong in terms of their attitude".
"I always give my best to score goals and I was able to find spaces in United's defence".
"I've sat in this chair twice before with Porto, Manchester United out, and Real Madrid, Manchester United out, so I don't think it's anything new for the club", he said about United's defeat in the last 16.
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Sevilla's 21 shots in the second leg was the most United had given up at home in a competitive match since 2013 - in that loss to Mourinho's Real Madrid. Premier League clubs in need of a solid midfield starter could do a lot worse than the two-time French worldwide, and I include United in that statement.
Questions will be asked as to why Mourinho switched around the team and formation from that game.
"Even though we didn't create chances in the first-half we put in a good performance".
Of course, a knockout tie in the Champions League is decided over 180 minutes, not 90. Sure, he delivered two trophies in his first season but at times his overly cautious approach to big games has been joyless and indefensible.
But the football this United team play - controlled and cautious - is hard to justify when it does not get results. "I knock out Manchester United at home at Old Trafford". We are also sad, and we have to win to go back to winning ways, so I hope that the team reaction is going to be good.
Marcus Rashford, so brilliant on the left with his two goals in the North West derby, was moved to the right flank while Alexis Sanchez, who had looked promising playing just behind Romelu Lukaku, was switched back to the left wing.