For fourth-seeded Arizona (27-8), it was one of the worst losses in school history.
The Sun Devils saw their season end at the hands of the Syracuse Orange 60-56 in the final First Four game in Dayton Wednesday, seeing numerous issues that put them on the tournament bubble cost them.
Since 1985, the Wildcats have suffered first-round losses 13 times. Harris had seven rebounds while Clark seven assists.
"With us being a MAC, it's easy to look at us as a team that can't compete with a high-major, a team that has four National Basketball Association prospects", Clark said. "We know deep down we watched enough film and had confidence that we can play with these guys". "Their guard play, their pressure defense, you know, they really took it to us".
Deandre Ayton scored 14 points and collecting 13 rebounds for his 24th double-double, which is now tied for the NCAA lead.
There's the rush of extra media attention and interviews leading up to the game - and of course, playing win-or-go-home games at the time of year when even casual college basketball fans are closely watching. However, he could not stop the Buffalo second half onslaught.
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"We ran into a team that played well on a night when we didn't", Arizona Coach Sean Miller said.
The game matched two of the highest-scoring teams in Division I - Buffalo entered ranked seventh with a 84.8 scoring average and Arizona was 41st at 80.9 - but the Bulls were the more aggressive team and took control in the second half behind their guard play.
The Wildcats wasted the rare opportunity of a once-in-a-generation talent in Ayton, plus a handful of talented supporting pieces in seniors Dusan Ristic and Parker Jackson-Cartwright, junior Allonzo Trier, and sophomore Rawle Alkins. "With our young guys and kind of early on in the season we had our bumps, but as the season progressed, you see those young guys learning". We thought we were better than that. His 23 double-doubles surpassed Al Fleming's 22 for the Wildcats in 1974-75 as the program's all-time mark while tying Kevin Love's Pac-12 freshman record from 2007-08.
It's a disappointing end for the conference that only put three teams in the field and lost UCLA and Arizona State in the First Four in Dayton. The top-ranked Arizona Wildcats saw their chances of becoming NCAA champions crumble apart as they fell apart to the Buffalo Bulls.
Buffalo went 15-3 in the Mid-American Conference and captured the league's regular season and tournament titles.
No. 5 Kentucky 78, No. 12 Davidson 73: Kentucky topped Davidson despite failing to make a 3-pointer, snapping a nation-best streak of 1,047 games with a 3 that began in 1988. Gonzaga-Ohio State is one matchup set for Saturday.