An amber weather warning for snow and ice is in place across north-west England, Yorkshire and the Midlands, as well as in London, the South East, and east of England, from 4pm on Saturday until 9am on Sunday, while a yellow warning for snow and ice in force for the entire day covers almost the whole of Britain.
Flights have been cancelled and several sporting events were also called off, including the Reading half-marathon.
Met Office meteorologist Alex Burkhill said: "It will be bitterly cold with some snow for many places over the weekend".
"The warning has been extended west across Cornwall, and also until 2100; this later clearance most likely in the far southwest".
Greater Manchester Police's traffic unit said conditions were "bleak" on the M62, with a video showing blizzard-like conditions.
And Meteo Radar also hosts a real-time snow radar for England and the United Kingdom, show where the blizzard will hit and what time.
There is then a yellow warning for ice out for Monday morning and the drive to work.
Meteorologist Martin Bowles said snow will first appear on Friday afternoon, impacting north-eastern Scotland and north-eastern England, before the weather front rolls across the rest of Britain.
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But I thought the killer was when those offensive rebounds or rebounds that we had on our hands, they were able to get those. Allowing the Bulldogs to outscore them 43-31. "And when they have an extra opportunity, those are killers for you".
There is also a warning for strong easterly winds will lead to some drifting of snow.
Dr Thomas Waite, a Consultant in Health Protection at Public Health England, said the freezing blast "may come as a shock to the system for some whose bodies may struggle to cope in cold weather".
More than 100 flights to and from Heathrow were cancelled on Saturday and the airport warned of the potential for more disruption.
National Rail has advised passengers to check for service disruptions before travelling.
Flight operations at Dublin airport were suspended for 40 minutes on Sunday morning to clear snow from the runway, but have since resumed.
The snow accumulations are likely to be in the eastern part of the country, but some will penetrate into the midlands and the south coast. The county is covered by a yellow weather warning issued by the Met Office and it is thought that five buildings were at risk.
A Met Office spokesperson added: "Ice is likely widely on roads, pavements and cycle paths". This increases the risk of accidents, as well as injuries due to falls.
And as our region and the rest of the country gears up for the chill, forecasters have issued a severe weather alert - while Highways England gritters prepare to set to work for a busy weekend.