The 72-year-old U Htin Kyaw was elected as president on March 30, 2016 after Aung San Suu Kyi-led National League for Democracy (NLD) won the 2015 general election with absolute majority votes.
According to various media reports, the presidential post will be filled within seven working days in line with the Article 73 (b) Myanmar's constitution.
His role was largely ceremonial given Suu Kyi had awarded herself the title State Counsellor and called the shots within her civilian administration.
The president's office did not give a reason for Htin Kyaw's resignation.
Htin Kyaw is the son of a revered poet and helped run Suu Kyi's charitable foundation before taking over the presidency.
James City County hosts Easter egg hunt for local children
After the march, there will be an Easter egg hunt around 12:30 p.m.at Harborfront park for children between 2 and 8. At the egg-stravaganza there will be plenty of photo moments with the Easter Bunny so be sure to bring your camera.
He resigned from that post on Wednesday. He was Myanmar's first civilian president and the head of its first government to be elected in free and fair polls.
"He is loyal and has been a member of the NLD since the party was founded", said Aung Shin, who lauded Win Myint's performance as the lower house speaker and said he has "worked very well with Daw Aung San Suu Kyi during the whole period". The move puts a representative of the country's already powerful military at least temporarily in a position of executive power, AP said.
Yangon-based diplomats say the relationship between Suu Kyi and the military chief, Min Aung Hlaing, is marked by mistrust and lack of frequent, open communication, highlighting a risk even in the smallest changes to the leadership structure.
In a varied career, he worked as a university teacher and also held positions in the finance and national planning and foreign affairs ministries in the late 1970s and 80s before retiring from government service as the military tightened its grip.