Iranian officials have made calls to Syrian leaders in the wake of the US -led airstrikes against Syrian targets.
The United States had Israel's full support as it led the attack on Syria's chemical weapons facilities together with its allies, France and Britain.
Israel on Saturday lauded the joint airstrikes on Syria by the U.S., Britain and France as an "appropriate" response to the alleged gas attack in Syria.
Netanyahu expressed his hope that Syrian President Assad would acknowledge that "his reckless efforts to acquire and use weapons of mass destruction, his wanton disregard for global law and his provision of a forward base for Iran and its proxies endanger Syria".
On Monday seven Iranian personnel were among 14 people killed in an early-morning strike on the T-4 airbase in Syria, with regime allies Iran and Russian Federation blaming Israel for the attack. If the USA withdraws from Syria, the source told Channel 10, "Israel remains alone, facing the threat of Iran establishing itself on the northern border". She acknowledged, however, that one of the goals of the strikes was to deter Syrian President Bashar Assad's government from using chemical weapons again. Syrian government has strongly denied the allegations.
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White House spokeswoman Sarah Huckabee Sanders says Trump held a meeting Thursday afternoon with his team to discuss the situation.
Israel has mounted air strikes in Syria on a regular basis, targeting suspected weapons shipments to Lebanese Hezbollah. "The real test now is the coalition's ability to maintain the military and diplomatic pressure on the dictator from Damascus".
They have been tasked with investigating the site of an April 7 attack in the town of Douma, just east of the capital Damascus, which Western powers said involved chlorine and sarin and killed dozens.
U.S. Defense Secretary Jim Mattis said the strikes were a "one-time shot" and that there was no additional action planned for the immediate future.
Trump later tweeted: "A perfectly executed strike last night".
The Pentagon, however, has claimed that the airstrikes "successfully hit every target".
The report quotes Khamenei as calling the leaders of the United States, Britain and France - the countries that launched the attack - "criminals".