Up to 10 missiles were destroyed by the Syrian Armed Forces, a military source told Sputnik.
The Pentagon on Monday denied any involvement in an attack on a Syrian air base outside Homs, not far from where USA, United Kingdom and French missiles struck early Saturday morning.
Raw video: Department of Defense releases footage of Tomahawk missiles fired from the USS Higgins toward targets in Syria on April 14th.
Syrian state television said the incident was an "aggression".
It is now unclear what the airstrike was targeting.
Hezbollah's AlManar TV reported that six missiles targeted Shayrat and three were aimed at Dumair military airport outside Homs on Monday.
They added that several explosions were heard near the base.
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Police attempted to pull the auto over but the driver refused to stop, got out of the vehicle and fled. Instead of stopping, police say he put his truck in reverse and drove away "at a high rate of speed".
A local reporter for The Arab News said Israeli warplanes were spotted in Syrian airspace just before the missiles were reported.
There are now no reports of targets hit in Damascus.
Syrian air defense systems have been activated in response to a missile attack apparently targeting Shayrat Airbase in Homs province, state media SANA reports.
A Pentagon spokesman said there was no USA military activity in that area at this time.
Syrian air defenses responded to a missile strike, believed to be carried out by Israel, that targeted two airbases in Syria after midnight Tuesday, according to the War Media, the media wing of the Syrian army.
The combined force deployed 105 total weapons against three targets that will significantly impact the Syrian regime's ability to develop, deploy and use chemical weapons in the future.