Being dependent on oral antibiotics? It may up kidney stones risk

Small children are prescribed antibiotics more than any other group

Small children are prescribed antibiotics more than any other group

There's been a 70 percent increase over the past 30 years.

The lead author, Dr. Gregory E. Tasian, a urologist at the Children's Hospital of Philadelphia, said the mechanism is unclear, but that the most likely explanation is a complex interaction of the drugs with the urinary or gut microbiome. Kidney stones were among the rare conditions in case of children in the past as of now.

He's the first who links antibiotics to kidney stones. While antibiotics are essential for stopping serious infections, Dr. Tasian says: "We should be using antibiotics appropriately and judiciously".

Tasian said, the study team has been dealing with the risk-beneficial relationship and are looking forward to ensuring that the antibiotics are prescribed without increasing the side effects on the health. For broad-spectrum penicillins, the increased risk was 27 per cent higher, the researchers added.

"Whenever I get a pain in the stomach, I think, 'Oh god kidney stones again, '" she says.

Background Although intestinal and urinary microbiome perturbations are associated with nephrolithiasis, whether antibiotics are a risk factor for this condition remains unknown.

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Tasian, Denburg and colleagues published their study today in the Journal of the American Society of Nephrology.

For their study, the investigators determined the association between 12 classes of oral antibiotics and nephrolithiasis in a population-based study within 641 general practices providing electronic health record data for more than a 13 million children and adults from 1994 to 2015 in the United Kingdom. For the study, the team analysed prior antibiotic exposure for almost 26,000 patients with kidney stones, compared to almost 260,000 control subjects.

They found that five classes of oral antibiotics were associated with a diagnosis of kidney stone disease. This can also get a solution to reduce the risks of kidney stones as well.

Conclusions Oral antibiotics associated with increased odds of nephrolithiasis, with the greatest odds for recent exposure and exposure at younger age.

Tasian pointed out that other researchers have found that roughly 30 percent of antibiotics prescribed in office visits are inappropriate, and children receive more antibiotics than any other age group, so the new findings reinforce the need for clinicians to be careful in prescribing correct antibiotics.

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