"Not everyone escaped, I think they were buried", Consuelo Hernandez told news outlet Diario de Centroamerica.
"Unfortunately, El Rodeo was buried, and we haven't been able to reach the La Libertad village because of the lava, and maybe there are people that died there, too", Sergio Cabanas, CONRED's general secretary, said on the radio.
The head of Guatemala's disaster agency said 33 people have been confirmed killed in the volcano's eruption, and the death toll is expected to rise further.
Hilda Lopez said her mother and sister were still missing after the slurry of hot gas, ash and rock roared into her village of San Miguel Los Lotes, just below the mountain's flanks.
Search and rescue operations had suspended due to low light and unsafe conditions, but were resumed early on Monday morning.
FILE: A soldier takes a rescued child covered with ash to a hospital after Fuego volcano erupted violently in El Rodeo, Guatemala June 3, 2018.
Dozens of videos making the rounds on social media and Guatemalan TV showing widespread devastation.
One village was extremely affected by running lava causing deaths and injuries.
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Ash fell on the Guatemala City area as well as the departments of Sacatepequez, Chimaltenango and Escuintla. Lava as hot as 1,300 degrees Fahrenheit (700 degrees Celsius) sped down the volcano's slopes and into the surrounding villages, covering roads, burning houses and hampering rescue efforts, Eddy Sánchez, director of the country's seismology and volcanology institute, told the Associated Press (AP).
President Jimmy Morales, who has declared three days of national mourning, visited the disaster zone.
Dense ash blasted out by the volcano shut down Guatemala City's global airport, civil aviation officials said.
The volcano is 27 miles (44 kilometers) west of Guatemala City and only about 10 miles (16 kilometers) from the colonial city of Antigua, one of Guatemala's most popular tourist destinations.
Workers and guests were evacuated from the La Reunion golf club near Antigua. "[I escaped] because we saw the lava was pouring through the cornfields and we ran toward the hills".
Volcan de Fuego, Spanish for "volcano of fire", exploded shortly after noon on Sunday.
Officials have advised people to wear masks as protection against falling ash in four of Guatemala's regions.
Disaster agency spokesman David de Leon says about 300 people have been evacuated from nearby villages, which are being blanketed by ash as fiery smoke billows almost four miles into the sky.