The Spaniard's 6-1 6-2 6-4 victory means Roger Federer can not catch him even if the Swiss goes on to win a ninth title at the All England Club.
De Minaur downed Italian Marco Cecchinato in four sets followed by another four-set victory over Frenchman Pierre-Hugues Herbert to advance to face the recently crowned 11-time French Open champion.
"I really take every match one at a time, not necessarily as it will be my last, but I try hard every time", Federer told BBC afterward. "If I am in the final, I prefer to face an easier opponent".
"I created more chances in the second set and was always able to stay pretty clean on my own service games".
Some may question the logic of sitting through a 100-minute programme about a ten-year-old tennis match so legendary that books have been written about it and it's the first thing so you see when you google the words "greatest tennis match ever".
The match was moved to a smaller court because previously scheduled matches on Court 1 ran long.
He won 7-6 (4), 7-6 (4), 7-6 (4) in the second round against Australia's John Millman.
"It's an awesome feeling, and I feel very proud I represent Greece and that all of my hard work has paid off, " Tsitsipas said.
Four Thai boys rescued as divers brace for next phase
Mr Nopparat Khanthavong, the 37-year-old head coach of the Moo Pa (Wild Boars) football team, had an appointment that morning. An entire floor of the 14-story hospital has been reserved for treating the soccer team, according to local media reports.
The 103rd-ranked McDonald, 23, who won the 2016 NCAA singles and doubles titles for UCLA, defeated Guido Pella 6-4, 6-4, 7-6 (6) as the Argentine player featured for a third consecutive day. The seven-time champion came from a break down in the first set to get past Kristina Mladenovic 7-5, 7-6 (2).
Federer has been the dominant player on grass on the men's circuit for more than a decade, but Nadal has experience of beating the Swiss legend on Centre Court at Wimbledon.
Before taking back the Wimbledon crown a year ago, Federer went four years without winning the grass court tournament.
She faces another mother in the fourth round Monday (Tuesday NZT): 120th-ranked qualifier Evgeniya Rodina of Russian Federation, who upset No. 10 seed Madison Keys of the U.S.
Williams is the only past Wimbledon champion remaining in the field.
Pliskova's opponent in the next round, Kiki Bertens, will be brimming confidence after knocking out five-times champion and ninth seed Venus Williams. Another statistic that makes this one seem like quite a mismatch: Federer is 5-0 against Mannarino, winning 12 of the 13 sets they've played. There are five of them - Roger Federer (1), Rafael Nadal (2), Juan Martin del Potro (5), Kevin Anderson (8) and John Isner (9) - who've sealed spots in the fourth round, as against just one among the ladies.
Isner is in the fourth round after a routine 6-3 6-3 6-4 win over Radu Albot.
Isner hit 21 aces and never faced a break point.