"George was treated and released from an Olbia hospital", the rep told "Good Morning America" in a statement Tuesday.
George, 57, was reportedly found lying injured on the road, having badly hurt his pelvis and bruised both his arms and legs.
Daily newspaper La Nuova Sardegna said the 57-year-old Clooney was heading to a film set a vehicle hit his motorbike.
Bertens stuns Pliskova as last top 10 seed falls
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News reporter Claudio Lavanga tweeted, citing police, that the accident happened around 8 a.m. local time. His helmet, which broke during the crash, is said to have smashed the Mercedes' windshield.
Local daily La Nuova Sardegna says Clooney's injuries aren't serious, but that he was taken to the John Paul II hospital emergency room.
It is reported that George was then x-rayed and seen to by a doctor, before being discharged the same morning and leaving the premises in a chauffeur driven vehicle. More information is to follow.
"Catch 22" is an adaptation of Joseph Heller's classic novel and George is directing and starring in the series.
The A-list couple are believed to have brought their parents to the Italian island to help care for the children while Clooney works.