The famous actor was taken to an emergency room in nearby Olbia, however, his injuries are said not to be serious.
The actor was given a CAT scan which showed that none of his bones had been fractured, according to local media reports.
Local daily La Nuova Sardegna said the 57-year-old Clooney had been headed to a film set on Tuesday when his motorbike was hit by a vehicle.
George Clooney has been involved in an accident. A vehicle did not respect the right of way and hit him.
George relocated his family to the idyllic Italian island for the summer to direct the forthcoming TV mini series.
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There is no definitive immunological measurement that is known to predict protection against HIV-1 in humans, they said. In the meantime, the vaccine will be tested on women in South Africa, who are most at risk of contracting the virus.
The story, set in Italy during World War 2, focuses on Christopher Abbott's character of Yossarian, a US Air Force bombardier who is furious because the bureaucratic rule known as Catch-22.
Immediately after the crash, Clooney was transported to a nearby hospital.
George and Amal were seen arrive in the island on a private jet at the end of June with their twins Alexander and Ella.
George and Amal met back in 2013 when Amal attended a party at the Ocean's Eleven star's house in Lake Como, Italy.