Big worry for England as the Indian openers are looking extremely solid in the middle.
The three-match ODI series starts at Trent Bridge, with the second game taking place at Lords on Saturday.
England's bid to avenge their T20 2-1 series defeat by India begins on Thursday when the two teams meet for the first encounter of their one day global series.
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In the bowling department, Kuldeep Yadav and Yuzvendra Chahal will once again be the key.
While England will welcome back the previously rested Mark Wood - Jake Ball, like Hales, is expected to miss out on his home ground - and the head coach, Trevor Bayliss, will be resuming duties after a break, India's attack has been depleted by Jasprit Bumrah's finger injury and Bhuvneshwar Kumar suffering from a stiff back.
Kuldeep (39 wickets in 20 ODIs at average 20.02) and Chahal (43 wickets in 23 ODIs at average 21.83) have proved their worth since making debuts but their ultimate test will be against England.
India need to win the series 3-0 to overtake England as the number one ODI side in ICC rankings. England have been one of the finest 50 over sides in recent times and India will have their task cut against a batting line-up comprising Jos Buttler, Jason Roy, Alex Hales, Jonny Bairstow and Eoin Morgan with Ben Stokes as all-rounder makes the English side a formidable team. England dominated Australia across five ODIs last month, including notching a record setting 481 innings runs when they played at Thursday's venue Trent Bridge.
With the ball, spinners Adil Rashid and Moeen Ali will be a major threat to the visitors.