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On what turned out to be the longest-ever semi-final day at Wimbledon, Anderson still had no idea who he would play in Sunday's final as Djokovic led Nadal by two sets to one when play was halted at 11.02pm on a floodlit Centre Court.
Great Britain's Jack Draper, 16, battled to victory in an incredible boys' singles semifinal that lasted 4 hours, 23 minutes, defeating Colombia's Nicolas Mejia on the 10th match point, 7-6 (5), 6-7 (8), 19-17.
The match surpassed the previous record set by another five-setter between Novak Djokovic and Juan Martin del Potro in a 2013 semifinal.
It was also the second longest match at a Slam, beating the six hours and 33 minutes which Fabrice Santoro spent seeing off Arnaud Clement in the 2004 French Open. At the end, you feel like this is a draw between the two of us, but somebody has to win. "Getting through something like that is quite hard".
"I apologise if I´m not more excited right now".
While Anderson-Isner was mostly a serving duel with a few longer rallies thrown in, Djokovic and Nadal repeatedly slugged it out from the baseline, chasing each other around the court and coming up with spectacular winners from every corner.
Another player who needed a decider was Rafa Nadal, as he squeezed past Juan Martin Del Potro to land us a victor from our recommended bet, but the after-effects of these arduous wins for Anderson and Nadal may not help them in their quest to reach Sunday's final.
His ultramarathon loss to Kevin Anderson, by that score and over all those hours, in the Wimbledon semifinals on Friday amounted to the longest Grand Slam singles semifinal in tennis history.
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For the first time in the Open era, the semi-finals were made up exclusively of players over 30.
If Nadal wins to advance to the Wimbledon Men's Final, and historically he's never lost a Wimbledon Men's Semi-Final match, then he and Djokovic will be tied at 26 against one another.
Yet Anderson's previously impenetrable serve suddenly looked vulnerable and in the very next game Isner broke back, once again taking the set thundering towards another tie-break.
The second semifinal of the day, pitting Rafael Nadal against Novak Djokovic, was easily the most highly-anticipated match of the tournament so far - and its start was delayed well over three hours as the city of London waited for either Isner or Anderson to blink.
Isner said that being part of yet another record-breaking match did not help ease his pain.
Meanwhile, Anderson didn't face a break point in the fifth set.
The American fends off another break chance at 10-10 and this insane encounter has turned into the longest Wimbledon semi-final in terms of time and the number of games, passing the insane semi-final clash between Goran Ivanisevic and Richard Krajicek that Goran won 15-13 in the fifth.
Anderson had a break point at 7-7 and at 10-10, but he missed the first one as Isner hit an ace and the second one as he mishit a backhand.