Rose, 32, is best known for her role in the Netflix series "Orange is the New Black".
The potential Batwoman series helms from Berlanti Productions in association with Warner Bros.
Caroline Dries will serve as the writer and executive producer on the project; she also worked on an early DC Comic TV show, Smallville, which told the story of a high school Clark Kent.
Her character is described in a CW release as a "highly trained street fighter primed to snuff out the failing city's criminal resurgence". The news of Ruby Rose's casting was confirmed by the official Arrow Twitter account, which posted an image of the actress alongside the titular hero she's set to play.
Ruby Rose is making history with her latest role as Batwoman, the first openly gay superhero to headline a TV series.
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Rucka, who had written Kate in her own title as well as in Detective Comics before leaving DC for a time, was generally supportive - although he wasn't sure anybody would notice.
Thoughts? Were you one of the many prescient armchair casting directors who predicted Rose's hiring?
The announcement comes after the network said it was searching for an openly lesbian actress to play Batwoman, whose real name is Kara Kane and who fights crime on the streets of Gotham.
The character of Batwoman, created two years later, and initially as a romantic interest for Batman, has often been seen as a reaction to that perception.
"Kate is fully aware of how bad-ass she is whenever she enters a room, even though she prefers to put a smile on your face". She went on to appear in films like "Resident Evil: The Final Chapter", "xXx: Return of Xander Cage", "John Wick: Chapter 2", and "Pitch Perfect 3".