It is understood that De Bruyne tore the lateral ligament in his right knee during training today.
A selection of Liverpool fans on social media are thrilled that Man City are set for a spell without their talisman and believe it could boost their own title bid.
The extent of the injury is not yet known but the staff at Man City are reportedly fearing that he could be ruled out of action for more than two months.
Though there's no official confirmation from the club, the fact there's talk that it's similar to the injury sustained in the Capital One Cup semi-final against Everton in January 2016 is incredibly concerning.
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De Bruyne had just returned to training August 6 after helping Belgium to the semifinals of the World Cup in Russian Federation.
This would be a huge blow to City's hopes of retaining their title, with De Bruyne having been so instrumental for the Citizens.
He was a second-half substitute in the 2-0 Premier League-opening victory over Arsenal on Sunday, coming on in the 60th minute.