Lloris, who was this week fined £50,000 and handed a 20-month ban after pleading guilty to drink-driving, had hoped to be fit to face Liverpool but a statement on Tottenham's official website confirmed he is expected to be out for "several weeks". He doesn't feel great.
Pochettino said that Lloris has beaten himself up over his mistake but deserved a second chance.
"It's a massive lesson for everyone". Like a man you need to recognise your mistake'.
Lloris admitted being more than twice above the drink-drive limit when he was stopped by police in central London last month.
It should have all been an exciting week for Spurs fans, with their new stadium due to open for the first time this weekend, but with the club having announced indefinite delays to their project, they face the hard challenge of hosting early Premier League leaders Liverpool at Wembley without two of their key players.
Like a man that he is, he is going to accept everything.' After initially being charged at the end of August, Pochettino stood by his goalkeeper and allowed him to wear the captain's armband in the 3-0 victory over Manchester United at Old Trafford.
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Dele suffered a muscle strain while being on national duty for England and the news had put Spurs fans on the edge of their seats.
Tottenham are also understood to have fined the World Cup victor £250,000, which is the equivalent of two weeks' wages, and warned him about his future conduct.
It seems likely both Spurs' captain and Alli will miss Tuesday's Champions League Group B match at Inter Milan too.
At least Son Heung-min is available again after helping South Korea win the Asian Games, which means he will be excused military service.
"Different clubs didn't allow him to go and play in this tournament", Pochettino said, before joking: "Who took the risk?"