The 49ers will now look to backup C.J. Beathard to turn their season around.
The 49ers will have to add a third quarterback either to the 53-man roster or the practice squad, and ESPN reported that the team would host former Texans passer Tom Savage, 28, who has started nine games since entering the league in 2014, for a workout.
The Niners struggled with Beathard and Brian Hoyer last season before the midseason addition of Garoppolo changed their fortunes. Beathard is now the only other quarterback on San Francisco's roster, so he'll presumably start in Garoppolo's absence barring a trade or free-agent signing.
Rod Rosenstein on his way to White House expecting to be fired
Trump was not at the White House; he traveled to New York City for the United Nations General Assembly. Solicitor General Noel Francisco would be in line to oversee the Russian Federation probe.
In three games this season, Garoppolo threw five touchdowns with three interceptions, as the Niners head into Week 4 with a 1-2 record.
Garoppolo's ousting is the 49ers second loss after top running back Jerick McKinnon, who endured a season-ending knee injury last month.
Expectations were high in San Francisco this season that the team could end a four-year playoff drought after Garoppolo had a full offseason to immerse himself in coach Kyle Shanahan's offense. "It really helps having gone through it and having that experience".