Most areas will start off the day with some intense bursts of rain, especially in the south west of England and Wales.
"We also have yellow and amber warnings of between 50mm and 150mm of rain for Wales".
Whilst the wind will generally be weaker than Friday, torrential rain could cause flooding, power cuts and isolate communities.
A yellow warning covers much of the rest of Wales, parts of Scotland, Northern and South West England - where power cuts and travel delays are expected.
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The CDC says that both the cause and long-term effects of the disease remain unknown. It may also be helpful to wash hands often with soap and water, the agency says.
The train operator said: "Due to the severe disruption to train services, lack of available road transport caused by local road conditions, customers are advised not to travel as journey completion can not be guaranteed".
The A5114 Glanhwfa Road at Llangefni, A4215 at Defynnog in Powys and A4059 in Aberdare, Rhondda Cynon Taff, were also shut on Friday.
Rail timetables in the South and North West have also been amended, while commuters in Northern Ireland were warned of disruption to services due to high winds.
Passengers are advised to check service updates with ferry companies before travelling from either Holyhead or Fishguard. The UK Met Office warned of "heavy rain during Friday and continuing into Saturday" with "fast flowing or deep floodwater" likely which may cause "danger to life".
Windsor, the scene of Friday's royal wedding, looks set to escape the worst of the storm.