Another Liverpool player, Naby Keita, went off with a suspected muscle strain in Guinea's 1-1 draw against Rwanda also on Tuesday.
That's with the Dutch defender playing through the pain of two broken ribs and taking painkilling injections to delay a spell on the sidelines.
Mane underwent an operation on Wednesday on his fractured thumb, sustained during Senegal's win over Sudan on Saturday.
There remain doubts surrounding Mo Salah and Sadio Mane with both carrying minor knocks but neither have been ruled out of the game at the John Smith's Stadium according to the German manager.
Cardi B admits baby Kulture broke her vagina during childbirth
I would like to do normal things with my baby, but right now I gotta keep it very low key". "I could do this over and over again", she added.
"I have known Jurgen long enough, I know he loves to use smokescreens", Wagner told a news conference on Thursday.
'They are ready but I have to make a decision how ready they are'.
"I have known him long enough and he likes to moan after the global break".
"Now we have a great opportunity, a wonderful game in front of our fans against a very strong side, where we can hopefully perform at the same level (as our last game)".
'You don't want to see Anthony Joshua fighting every other night.
Information from Reuters was used in this story.