Liverpool will also be without club captain Jordan Henderson and Nathaniel Clyne due to a hamstring issue and illness respectively, but Naby Keita and Dejan Lovren could feature.
Crvena Zvezda fans had a choice greeting for Liverpool when the two sides met in Belgrade for their UEFA Champions League Group C clash on Tuesday - with a pre-match choregraphed rendition of "F*ck you Liverpool".
"We are Liverpool, a big club, a football team but we don't have any message further than that". One thing that's for certain is that the Serbian Champions have an impressive home record and have not lost in their last 33 games in all competitions.
Despite settling in very well at Liverpool and turning into one of the bargain signings of the summer, Jurgen Klopp has taken the decision to leave the in-form attacker out of his plans for Tuesday's trip to the Serbian capital.
Liverpool still have Napoli and Paris Saint-Germain to play and must now do it the hard way to finish in the top two.
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Demi's visit to LA comes after it was reported that she is considering not returning to the Southern California city permanently. A day before the date night, Lovato enjoyed the scares at Universal Studios Hollywood's Halloween Horror Nights.
Liverpool were held in their last Premier League game and dropped to third in the league table, so they will look to get back to winning ways.
Last time in the Champions League at home, Red Star drew 0-0 with Napoli so expect a tough evening for Jurgen Klopp's side as they get to grips with the fiery atmosphere of the home support.
The outstanding Borjan again denied Salah from close range in the 82nd minute as Liverpool piled on the pressure but the visitors could not find a way through Red Star's packed and well-organised defence.
Two weeks ago, Liverpool routed Red Star 4-0 at Anfield.
Speaking to Sky Sports, Nicholas said: "This is a volatile situation so not taking Xherdan Shaqiri they're trying to diffuse the situation".
"The front three still aren't firing on all cylinders but they're still a handful, especially Sadio Mane".