The Three Lions now turn their attentions to a crucial UEFA Nations League tie at home to Croatia on Sunday.
So the former Manchester United star bows out of the worldwide game with 53 goals to his name.
The Three Lions took on rumoured Reds target Christian Pulisic and his American colleagues at Wembley, in what nearly felt more like a testimonial, with Wayne Rooney returning to the global fold one final time.
Wilson said: "Wayne is a legend for England, he has achieved so much throughout his career and to share the pitch with him was a great honour".
"His chapter is ending now and mine is just starting". It's a moment I'll treasure for the rest of my life.
The DC United striker broke down in tears as he gave a farewell speech in the dressing-room after his final England appearance.
Premier League To Introduce Controversial VAR Next Season
Key learnings from VAR's use in the FA Cup and Carabao Cup, and other leagues across the world, were discussed in detail . Managers Mark Hughes and Slavisa Jokanovic were the latest this weekend to be outraged at decisions going against them.
If taking Michael Owen's spot as the youngest Liverpool player for score for England wasn't enough, the 20-year old kept things tidy at the back - including helping to keep fellow up and comer and perennial Liverpool target Christian Pulisic quiet as the Borussia Dortmund attacker switched between the wings and ran between the lines on what was ultimately a frustrating night for the American global.
"The way they are being coached is brilliant, it's a great group of young players who have a bright future".
"I'm sure in the next few years they will go close to bringing a trophy back".
"Being around the players has been great; seeing how they're working and how they're improving has been great for me".
Rooney was honoured before the game with a guard of honour and the presentation of a plaque bearing a golden Three Lions badge by current skipper Harry Kane.
Southgate said: "It would have been flawless for Wayne to score but we saw moments of real quality from him".
" We were caught in transition and wide open".