In this study, a patient in the treatment arm stayed on that dose for another six months, and then was given an oral challenge to peanut. After nine to 12 months of treatment, the study showed that two-thirds of those who took the peanut allergy drug were able to tolerate two peanuts a day.
A peanut allergy is potentially life-threatening and is very rarely outgrown, affecting about 1 in 50 children in the UK.
Children with peanut allergies may benefit from a breakthrough treatment developed at University College Cork.
Qualifying participants started with a one-day supervised increase in dosage from 0.5 mg of peanut protein up to 6 mg, an increase every two weeks from 3 mg to 240 mg and a 24-week "maintenance phase" at 300 mg.
The immunotherapy trial will be submitted to the US Food and Drug Administration for a Biologics Licence Application by the end of the year.
A successful study of the new peanut allergy treatment saw roughly two thirds of patients able to consume small amounts of peanuts without suffering from a severe reaction. He carried his own cupcake to school birthday parties, cultivated the habit of reading food labels, and became a grown up without tasting a Kit Kat, Twix or Three Musketeers bar which all entailed a detection of peanut as they rendered in prerequisite that process the nuts.
Professor George du Toit, paediatric allergy consultant at Evelina London and the study's chief investigator, said: "Peanut allergy is extremely hard to manage for children and their families, as they have to follow a strict peanut-free diet".
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An experimental drug derived from peanuts can turn cases of peanut allergies around, according to a study reported in the New England Journal of Medicine.
Research is looking at ways to desensitise some food allergens, such as peanuts and milk, but this is not an established treatment yet.
In the yearlong clinical trial, 842 participants, including 750 children and adolescents, were exposed to peanut protein in gradually increasing quantities to reduce allergy sensitivity, under strict medical supervision and starting with minute quantities. "The effect in participants 18 to 55 years of age was not significant".
The allergy persists into adulthood and can be life-threatening.
The youngsters not normally able to tolerate exposure to even a tenth of a single peanut could eventually cope with two whole peanuts, the trial found.
"Almost 6 million American children are now living with a life-threatening food allergy", said Ciaccio.
"The hope would be to have a treatment available in the second half of 2019", Lieberman said.