Then came the red card for Vertonghen, shown his second yellow for a strong challenge on Lacazette, as Arsenal saw things through pretty comfortably to extend their unbeaten run to 19 matches in all competitions.
Aubameyang had Arsenal in front within 10 minutes from the penalty spot after Jan Vertonghen had handled in the area.
Instead, most Arsenal and Spurs players were embroiled in a confrontation that had been triggered by Dier's reaction to his goal, with furious remonstrations by Gooners on the pitch and on the sidelines.
The German midfielder was left to sit on the Gunners' bench last week, as Emery admitted Ozil was not suited to a "very demanding match with physicality and intensity".
23-year-old defender Holding, who has been a regular so far this season, is looking forward to the derby atmosphere and is relishing testing himself against England captain Kane, who has scored seven league goals in 13 appearances this season.
Bernd Leno of Arsenal.
Winning Springbok Naka Drotske shot in robbery
Meanwhile, News24 reports that police say two men have been taken in for questioning in connection with the attack. We wish him a speedy recovery", South African Rugby said on its Twitter feed.
Now we are in front of Tottenham and we play against Manchester United, also a big team.
Arsenal reacted well and were nearly level on the stroke of half-time as Mustafi's looping header came back off the crossbar.
"He has a back ache", Emery said.
The strike reinvigorated Arsenal and they were so close to reclaiming the lead on the hour-mark.
Bellerin nearly gifted Tottenham a third, passing the ball across goal straight to Son, who could not beat Leno with the resulting strike.
Ramsey set up Pierre-Emerick Aubameyang for Arsenal's equaliser and assisted Lacazette to make it 3-2, before Lucas Torreira finished off the win.
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