Russian cosmonaut Oleg Kononenko, American astronaut Anne McClain and Canadian astronaut David Saint-Jacques successfully launched at 6:31 a.m. ET from the Baikonur Cosmodrome in Kazakhstan and went into orbit a short time later.
The incident was the first manned launch failure for the Russian space programme since September 1983, when a Soyuz craft exploded on the launch pad. The spacecraft made four orbits over six hours as it chased down the space station for the docking.
The launch was closely scrutinised because of the abortive mission to the ISS on October 11, which ended two minutes after take-off when a rocket failure forced its two-man crew to perform an emergency landing.
The new crew to the station will be tasked with a number of experiments for various organizations on Earth, including biology, Earth science, human research, physical sciences and technology development.
The new arrivals to the ISS join the European Space Agency's Alexander Gerst, NASA's Serena Auñón-Chancellor and Russia's Sergey Prokopyev, who have been in orbit since June but are due to fly back to Earth on December 20.
CNN's New York offices evacuated after bomb threat, no explosive found
Outside the building, CNN's Brian Stelter and Don Lemon continued to broadcast. "We were evacuated in the middle of my live show". Columbus Circle is where the Time Warner Centre is located. "We are now searching the entire building".
About two minutes into the fight, the boosters separated as planned, passing the point where the rocket had failed during the launch October 11. The Monday launch marks the Soyuz's return to form.
The families of the crew, other astronauts and space officials from several nations breathed a sigh of relief after observing the flawless launch, with October's Soyuz rocket failure still on the minds of many.
He'll be observing the effects of space on bone density, ocular pressure, and even the brain - all in the hopes of helping NASA figure out how to physically prepare astronauts for a potential mission to Mars.
Some of the investigations they will conduct are sponsored by the U.S. National Laboratory on the space station, which Congress designated in 2005 to maximize its use for improving quality of life on Earth.
Those plans were expected to change after the Soyuz MS-10 abort, as Al Mansouri would have returned on Soyuz MS-10, with Hague and Ovchinin, after a brief stay on the station had that mission flown as planned.