"This award is very big for me, I love it because I saw it when I was young and I always had a dream to win it one day", Salah said when collecting his trophy for his 2018 exploits.
Meanwhile, Morocco global and Borussia Dortmund defender Achraf Hakimi, who won the 2018 African Youth Player of the Year award, failed to make the team. Hours earlier, his country had been awarded the hosting rights for the 2019 Africa Cup of Nations after the CAF had stripped original hosts Cameroon of the honour.
While the Egyptian is keeping the coveted award for the second time in a row, Nigeria's Asisat Oshoala has been dethroned as the best female player on the continent.
Salah has hit the ground running this season as well, racking up 16 goals to guide Liverpool to the top of the Premier League table.
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Salah blossomed in Rome, averaging close to a goal every two matches, and Liverpool paid nearly €41 millionn (£37 million) to sign him two years ago.
He also scored twice for the Pharaohs at the Russia World Cup.
South Africa's Chrestinah Thembi Kgatlana was crowned the best in the women's category.
He became the first player to do so after Ivory Coast's Yaya Toure, who claimed it four years in a row between 2011 and 2014.
Men's National Team of the Year: Madagascar, Mauritania, Uganda.
After accepting his award, the 26-year-old striker looked shocked as the event organisers in Senegal brought up a live band to lay.