So far Missouri has had the worst of the snow, with more than a foot (30cm) on Saturday morning around St Louis and Jefferson City.
A massive winter storm hit the U.S. Rockies and Plains on Friday then punched east, with snow set to assault a 1,800-mile (1,609 km) corridor through the weekend, creating transportation "havoc" in the middle of the country. The Indiana State Police confirmed one death in that state.
As the storm heads east, up to 16 inches (41 cm) of snow were likely in western Missouri and St. Louis.
Between 3 and 6 inches (7 and 15 centimeters) is expected in the Washington area, including parts of northern and central Maryland, by Sunday. Forecasters said heavy snow could fall in mountain areas north of Interstate 64, such as Charlottesville and Staunton, Virginia.
St. Louis had recorded 10.4 inches of snow by 1:30 p.m. ET, with higher accumulations in other parts of Missouri.
"So, by that time, most of the snow will have already fallen, but there will still be flurries through the beginning of the game", she said.
Seals Overrun Town After Bay Waters Freeze, Block Them from the Ocean
Fitzgerald says residents will be able to call in seal sightings and have officials transport the animals back out to safety. But this week, that small Canadian town is on the map because of a different animal: the harp seal.
Authorities in Kansas and Missouri reported at least three people killed in each state, majority in vehicle accidents. They said among those killed in the crashes were a woman and her 14-year-old stepdaughter whose vehicle slid into the path of a semitrailer on Friday in Clinton, about 80 miles southeast of Kansas City.
Another woman's auto slid into the path of an SUV in northern Missouri, a 62-year-old man in Kansas died after his truck skidded and hit a concrete barrier and two vehicles collided killing a 41-year-old man from Mexico.
In Kansas, the Highway Patrol says a 62-year-old man died after his pickup truck skidded on the Kansas Turnpike and hit a concrete barrier. "If you do have to get out on the road, we're asking you to do three things: Have your cellphone fully charged, wear your seat belt and slow your speed for the conditions".
Meanwhile, the Missouri State Highway Patrol said it has responded to almost 4,000 calls for help and rescued almost 1,800 stranded motorists. Up to 11 inches (28 centimeters) of snow was reported in St. Louis.
St. Louis Lambert International Airport spokesman Jeff Lea says airlines are canceling dozens of flights through Saturday morning.