Guardiola refused to be drawn on the chances of signing the 21-year-old Netherlands global, who could cost around £70 million, but admitted it's hard to take on the La Liga giants.
Nuno Espirito Santo's side held City to a draw at Molineux earlier in the season and now sit ninth in the Premier League table.
"It's going to be a very hard match, they have players who know each other very well". But of course, for the next season, it's an important target to find. "But if you want a certain player and there are lots and lots of clubs that want him, then it's more complicated, especially if the other clubs are Real Madrid and Barcelona". He'll be 34 and he can not play every few days.
City host Wolves in the Premier League on Monday as they aim to close the gap to leaders Liverpool to four points. "There are many players and this doesn't happen in isolation". But he's an excellent player.
"The system at Wolves involves playing with two holding midfielders, not just one".
But with City still fighting for silverware on four fronts, the Catalan is happy to rely on John Stones and Ilkay Gundogan until the end of the season.
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"Most of them are under contracts". "But a month ago, I started reading, "Ruben Neves, £100 million" - that is not going to happen, we are not going to pay £100 million for a holding midfielder".
Wolves's reported asking price of £100 million is beyond... He can play that holding midfield role, he has the quality and the vision to pass.
However, Guardiola says he does not know if the player is angry with him or not, as De Bruyne has not sought a conversation with him about the incident.
"I reflected on it briefly and wondered if they were talking correctly and said, 'No, I can not accept it, come on Spurs!'" It looks simple but it's not simple. "We put our standards high", he says. "I don't talk about players not here, never did and never will".
Guardiola said: "If he has a problem, he knows where I am, so I don't know, really".