Gum infection could be linked to Alzheimer’s, study says

A simple blood test could predict if a patient will develop Alzheimer's disease up to 16 years before symptoms begin a new study finds

A simple blood test could predict if a patient will develop Alzheimer's disease up to 16 years before symptoms begin a new study finds

In the brain, this protein damage may spur the formation of tangles, they say.

The study authors say these results, plus additional testing in mice, provide "solid evidence" of a link between the two diseases and may offer a potential new way to treat Alzheimer's. He hopes the test will allow researchers to monitor the effectiveness of new treatments before people have started to experience symptoms, by measuring how levels of the protein are affected.

Biotech start-up Cortexyme, Inc., who sponsored the new research, has previously shown a similar drug to be safe and tolerable in both healthy old people and those with Alzheimer's in a Phase 1 clinical trial.

Risk Factors involved with the disease and that age is the greatest known risk factor for Alzheimer's, include an individuals risk for developing Alzheimer's increases after the age of 65, having a parent or sibling with the disease increases an individuals risk and 5.7 million people are now living with Alzheimer's.

Alzheimer's disease is widely believed to be caused by the accumulation of beta-amyloid proteins which clump together to form plaques between neurons and disrupt cell function.

These findings suggest that it's the other way around, and that the control patients might have gone on to develop the disease if they had lived longer and the gingipains had built up more.

Doctors have observed that gingivitis is more common among people with Alzheimer's disease, although that could be because these people find dental hygiene more challenging.

"We want to break the stigma by not just talking about it, but by letting people know that there is help out there, you're not the only one to have it and it's definitely ok to talk about it".

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Jucker's team measured the rate of change in NfL using a blood test in 405 individuals from across the world enrolled in the Dominantly Inherited Alzheimer's Network - an global research effort focused on dominantly inherited Alzheimer's disease, a rare form of the illness that represents less than 1% of all cases of Alzheimer's, according to the National Institute on Aging.

People with Alzheimer's are more susceptible to getting infections in their brains, so it may be that the gum disease bacteria and the toxic proteins they secrete are a by-product of Alzheimer's rather than a cause. The study is ongoing.

While taking care of your teeth and gums is an important part of healthy aging, Edelmayer says it's too early to say if those steps could help prevent Alzheimer's disease. Inherited Alzheimer's is rare genetic disease. Clinical trials on Alzheimer's patients will be carried out this year. Higher levels of neurofilament indicate brain damage, but this can also be due to brain injury from an accident, for example. First, though, the drugs need to be tested on people.

The study, by USA company Cortexyme, says P.?gingivalis plays a "central role" in the development of Alzheimer's.

In 2014, using a blood test that looked at 10 specific lipids in people's blood, researchers were also able to predict Alzheimer's before symptoms appeared.

Senior author Dr David Holtzman who is head of the Department of Neurology, said: 'The interesting thing about this study is that it suggests that real-life factors such as sleep might affect how fast the disease spreads through the brain.

The researchers who carried out the study mostly worked at Cortexyme, a private biotech company, with others working at Jagiellonian University in Poland, the University of California, University of Louisville School of Dentistry and Harvard University School of Dental Medicine in the United States, the University of Melbourne in Australia, and University of Auckland in New Zealand.

Now, researchers at Cortexyme, an American pharmaceutical corporation who has invested heavily in gum disease research, add even more weight to the gum disease-Alzheimer's association.

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