If going to the Parc des Princes two goals down wasn't tough enough already, a late red card means United will have to attempt a comeback without Paul Pogba.
United were in the midst of an 11-game unbeaten streak since December but the Red Devils crashed to their first defeat under caretaker manager Ole Gunnar Solskjaer. "It was not easy with injuries [Neymar, Edinson Cavani] but we have great players, a great team, the match is flawless tonight".
Angel di Maria was roundly booed by the home support on his return to Old Trafford after an unhappy one-season spell with United after signing for a then club record £60 million in 2014. "Maybe he was a bit nervous and a bit overused because he plays all the time for us".
Prior to facing PSG, United have an FA Cup meeting with Chelsea to take in, along with Premier League outings against Liverpool, Crystal Palace and Southampton.
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Neville gives them little chance of turning the tie on its head, with it likely that the hosts will have Edinson Cavani back in their side by then - even if Brazilian superstar Neymar will still be sidelined. "I think that it is over at 3-0".
Despite their depleted ranks, PSG ran out worthy winners and United lost by more than one goal in a home European tie for the first time.
"In the first half I thought they didn't cause us too many problems, but we didn't really cause them too many problems either", he said.
In fact, some of the events that have happened since Moyeseh led United to a win are quite remarkable and a detailed list has been compiled by BT Sport.
The Serbian has played an important role in the heart of midfield under Solskjaer, and the pressure will be on him to produce again following Pogba's moment of madness that sees him suspended for the return leg.