NASA astronauts Anne McClain and Christina Koch are scheduled to suit up and head outside the International Space Station.
Koch and McClain's spacewalk is set to last for about seven hours and will be broadcast on NASA TV.
Spacewalks are held for a number of different reasons, according to NASA, including doing work outside a spacecraft, conducting science experiments and testing new equipment.
"As now scheduled, the March 29 spacewalk will be the first with only women", NASA spokeswoman Stephanie Schierholz told CNN in an emailed statement-the only mention of the all-female excursion. Schedules and assignments for EVA missions can change, but it will be a spacewalk for the history books if all goes as planned.
Valentina Tereshkova, from the Soviet Union, was the first woman in space in 1963.
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The goal of the spacewalk is to upgrade batteries at the space station, which were delivered last summer.
In the almost 60 years of spaceflight, there have only been four times when expeditions included two female members trained for spacewalks.
The on-the-ground flight control team at NASA's Johnson Space Center in Houston will include lead flight director Mary Lawrence and NASA engineer Kristen Facciol.
The first woman to walk in space was Svetlana Savitskaya in July 1984 and since 1998, the space station has hosted 213 spacewalks, USA Today reported. Anne also will join Nick Hague for the March 22 spacewalk.
The spacewalk is taking place during Women's History Month, but a Nasa spokesperson said it had "not been orchestrated to be this way". McClain is on the ISS right now, while Koch will head to space on March 14 to prepare for the mission.
Nasa astronauts Anne McClain and Christina Koch will follow in the footsteps of Soviet cosmonaut Svetlana Savitskaya, the first woman to walk in space nearly 35 years ago.