For the Rennes game, Shkodran Mustafi comes into the side in place of the suspended Sokratis, while Petr Cech replaces Bernd Leno in goal, as he has been the regular goalkeeper during cup games for Arsenal this season.
Arsenal manager Unai Emery hailed his side's ability to cope under pressure after they came back from a 3-1 loss in the first leg of their Europa League last-16 tie with Rennes to win 3-0 on Thursday and advance 4-3 on aggregate.
Arsenal got off to a brilliant start thanks to superstar Pierre-Emerick Aubameyang, who scored in the fifth minute to put Arsenal in the driver's seat.
"Today we gave ourselves the chance for me to finish like this".
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Arsenal completed an impressive comeback in the UEFA Europa League as they eliminated Rennes following a 3-0 win at the Emirates Stadium.
Pierre-Emerick Aubameyang opened the scoring in the fifth minute then crossed for Ainsley Maitland-Niles to level the tie on aggregate, the Gabon global later scoring a second-half clincher.
The game kicks off 9 pm West African time. You know that you need the third goal regardless, and even then, if they score once, you're going to extra time.
"We can be proud of our players today because it was a very hard week - (Manchester) United on Sunday and today against Rennes".