In the backs, Jack Nowell replaces Joe Cokanasiga on the right wing and Henry Slade replaces Ben Te'o who drops to the bench.
"My clear goal is to be in this side for the World Cup in 2019 and we have unbelievable potential here".
"Scotland are a hard side - they are always at you, they play with a lot of enthusiasm and effort and have got a lot of attacking strings to their bow".
"We just feel it's right for him not be involved in matchday squad but he'll still learn from being around the squad". We came in at half-time determined to play a bit tighter and with a bit more discipline, but we failed to do that.
"We might have short memories sometimes, but sometimes you have longer memories", Jones recalled, without elaborating of what exactly annoyed him.
"We've got a plan in place for him, a good plan in place for him, he'll be ready by the World Cup".
In total there are four changes in personnel to the XV that battered Italy 57-14 at Twickenham with Ben Moon restored at loosehead prop and Mark Wilson displacing Brad Shields at blindside flanker.
Saturday's game will also see Leicester Tigers' Ben Youngs reach a milestone as he is set to become the most-capped scrum-half for England with his 85th Test appearance.
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A couple of spots are still up for grabs and even those are expected to be filled after the ongoing ODI series against Australia.
But if the Welsh lose, England will take the title instead if they beat the Scots.
Against South Africa last summer England were guilty of letting leads slip and against Wales in round three Eddie Jones's side could not stem the second-half tide.
"With young players, particularly in this environment, you've got to look after them", England's head coach said.
They did beat England in Edinburgh a year ago when they outmuscled Jones's team at the ruck and the Australian said he expected a different scenario on Saturday after overseeing a massive improvement in that area, and in their discipline.
Whatever happens, England will have had a far better Championship after losing their last three Six Nations matches to finish fifth last season.
Wales received the Grand Slam trophy at the Principality Stadium just moments before Eddie Jones' players exited the tunnel, a 25-7 victory over Ireland elevating them to the pinnacle of European rugby. Sometimes you push young guys forward and sometimes you've got to pull them back.
But Stuart McInally's score before half-time brought Scotland back into contention and they were sensationally level with around 20 minutes to play, before Sam Johnson looked to have completed an incredible turnaround.