One of the most notorious gangs of NY is at the center of a new mob murder mystery.
NY media reported that 53-year-old Cali was shot multiple times outside his vehicle on Staten Island on Wednesday evening, local time, by an unidentified man who then fled the scene in a blue auto.
In 1992, Gotti was convicted in Castellano's murder and a multitude of other crimes.
Aggressive federal prosecutions in the past 25 years decimated the ranks of New York's five Mafia families.
The murder reminded Mob fans of the last NY "hit" on a Mafia boss, almost 40 years ago.
Police confirmed the identity of Cali, who was pronounced dead at Staten Island University Hospital.
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"There are no arrests and the investigation is ongoing", police said in a statement.
Fox News noted, "Cali, who had roots in Sicily and ties to the Sicilian Mafia, was the highest-ranking organized crime figure to be murdered in New York City since 1985, when Paul Castellano was assassinated as he arrived as Sparks Steakhouse in Manhattan, according to WPIX-TV".
"We thought those days were over", Mayor Bill de Blasio said of Cali's slaying.
The reputed "acting boss" of the storied Gambino Crime Family was found shot to death outside his home Wednesday evening. "The word that I'm hearing is this: That there's old school tension and friction".
Cali himself was jailed for 16 months for his connection to an extortion scheme surrounding an attempt to build a NASCAR track on Staten Island. He was shot on a tree-lined street in one of New York City's less-glamorous outer boroughs, a short walk from ball fields, a country club and a day camp. He was sentenced to life in prison and died of cancer in 2002.
After prosecutors called him "a danger to the community" Pandrella, 59, pleaded not guilty in Brooklyn federal court to accusations of shooting Zito in his own home and stealing money from him.
Last October, Bonanno crime family associate Sylvester Zottola, 71, was gunned down at a Bronx McDonald's drive-thru as he waited for a coffee.