Tadgh Beirne and James Ryan are partnered in the second row with Peter O'Mahony, Sean O'Brien and CJ Stander named in the backrow.
The front row remains unchanged with Cian Healy and Tadhg Furlong either side of captain Rory Best, who will make his final championship appearance.
Subs: 16 Rory Scannell, 17 Dave Kilcoyne, 18 Andrew Porter, 19 Quinn Roux, 20 Jack Conan, 21 Kieran Marmion, 22 Jack Carty, 23 Jordan Larmour.
Eddie Jones has ramped up the pressure on Wales ahead of their Guinness Six Nation Grand Slam bid by claiming that Warren Gatland's side are "looking tired" and will face an Ireland team who are "peaking" in Cardiff on Saturday.
Joey Carbery misses out due to a hamstring injury so Connacht's Carty covers fly-half from the bench.
Kearney had to pull out of their game against France at the last minute and was replaced by Jordan Larmour, who now drops to the bench.
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The camera attached to his head recording the massacre follows the barrel of his weapon, like some macabre video game. Two other people were being held in custody and police said they were trying to determine how they might be involved.
Schmidt backed tournament rookie Beirne to shine on his return to Welsh soil.
"He would have liked to have had a bit more game time leading into it and it's one of those things that you'd love to go two weeks in a row with the same team". 'If it was me, I'd be concentrating on playing Scotland.
"That's been a really positive challenge for us throughout the Six Nations, to still try to get some cohesion. He knows his Scarlets team-mates very well". I've got no comment on Eddie Jones talking about us.
"To say that was not his best performance, I know he'd agree with that", said Schmidt.
It will be his final match in charge of Wales in the competition, with the New Zealander stepping down after this year's World Cup.