Belinda Bencic of Switzerland celebrates after defeating the number one Naomi Osaka of Japan during the BNP Paribas Open tennis tournament at the Indian Wells Tennis Garden in Indian Wells, California.
Nishioka squandered a 5-1 lead in the third set but took advantage of loose play from the 18-year-old Montreal native to win the final four points of the 2 hour, 55 minute match.
Recalling her loss to Bencic at last year's Hopman Cup, the Japanese, who is seeking her first title defence, said: "That's really incredible, the fact that she was able to come back from her injury and still play at a really top level". "But I feel pretty good right now, because I think, given the circumstances, I tried my best and I don't really have any regrets".
Kohlschreiber, 35, stunned the top seed and five-time former champion 6-4, 6-4 in Indian Wells.
She will face resurgent Swiss Belinda Bencic, a 6-4, 6-2 victor over Ekaterina Alexandrova of Russian Federation.
But there were no tears on Tuesday as Osaka said she was adjusting to being the world number one and always having a target on her back.
Earlier in the day, Czech teenager Marketa Vondrousova ran Halep ragged before dumping the Romanian out of the tournament 6-2 3-6 6-2.
"I think it's always a bit tricky whenever you change someone in the team, but I feel like for a first tournament we did really well", she said of her partnership with Jenkins, a former USA collegiate star who served as a hitting partner to Venus Williams from 2015 until the end of last season. "I was just fighting for every point".
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Hurkacz, unseeded, reached the fourth round of a Masters 1000 event for the first time in his career.
In-form Swiss Bencic blitzed the top seed, who surprisingly relinquished her crown following 28 unforced errors and just 10 winners. No. 8 Angelique Kerber outlasted qualifier Natalia Vikhlyantseva 3-6, 6-1, 6-3 and No. 9 Aryna Sabalenka defeated 24th-seeded Lesia Tsurenko 6-2, 7-5.
"I didn't play that well", Osaka said.
She will play either Ukraine's Elina Svitolina or Australian Ashleigh Barty in the last eight.
But Kerber - the eighth seed - rallied to secure a meeting with 2018 semi-finalist Williams, who defeated Mona Barthel 6-4 6-4.
"I felt somehow odd and the match was unusual", said Pliskova.
Spain's Muguruza, a two-time Grand Slam champion now ranked 20th in the world, out-lasted seventh-ranked Kiki Bertens 5-7, 6-1, 6-4 while Williams, a seven-time Grand Slam victor, beat Germany's Mona Barthel 6-4, 6-4.