"If anyone is thinking of a legal challenge we are absolutely comfortable that we will win that case", de Blasio said.
US cities have fined residents before for not being vaccinated, but "not in our modern history", said Lawrence Gostin, a Georgetown Law professor focused on public health law.
The leaders of the Orthodox Jewish community support people getting vaccinated, but uptake of the MMR vaccine has been low in the community itself, with resistance being "fueled by a small group of anti-vaxxers in these neighborhoods".
"As a parent, I have no doubt that each and every parent is making decisions based out of what they believe is best for their children", said Deputy Mayor for Health and Human Services Dr. Herminia Palacio.
What's more, the more children in the community have it, the higher risk of exposure for kids with weakened immune systems and pregnant women, who need to avoid the virus. "We're hoping people will comply", Miranda said.
In March. a county in NY state declared a state of emergency following a measles outbreak. Israel, for instance, also has a current measles outbreak. Others remain convinced, against expert assurances, that vaccines are unsafe.
"It's true that a lot of people have measles and measles are not a very good thing, but I think the vaccine also not a very good thing", said Aron Braver, a neighbourhood resident.
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"And it's everybody's option to do what he wants".
Earlier this week, the city ordered religious schools and day care programs serving that community to exclude unvaccinated students or risk being closed down. Most of these measles cases were unvaccinated or incompletely vaccinated individuals.
There have been 285 cases in the Brooklyn area since September 30.
Health officials also expressed alarm at reports of parents in the city holding so-called "measles parties" where they intentionally expose their unvaccinated children to an infected child in the mistaken belief doing so is a safe means to create immunity. It's in these areas where there's potential for a lot of measles spread.
Measles is a highly contagious viral disease that can result in serious health complications, such as pneumonia and swelling of the brain.
People are infectious from five days before the onset of the rash to five days after the rash starts.
Video: Despite evidence that vaccines are safe and effective, the anti-vaccination movement is gaining strength. MMR is available from your family practice and is free to eligible persons.
Unvaccinated residents living in the ZIP codes 11205, 11206, 11211 and 11249 are required to receive the measles-mumps-rubella vaccine to stymie the outbreak.